加速表观遗传年龄与老年人全脑功能连接和认知能力受损有关
Andrew J Graves1, Joshua S Danoff1, Minah Kim1
1University of Virginia, Charlottesville, USA.
Scientific reports
|April 26, 2024
概括
加快表观遗传衰老与老年人认知功能较差有关. 大脑连接,特别是在中间叶,可能会解释这种关系,突出表观遗传学.
科学领域:
- 表观遗传学和神经科学研究.
- 衰老和认知功能研究.
背景情况:
- 年代年龄是个体衰老的不完美的衡量标准.
- 表观遗传生物标志物提供了更个性化的生物衰老观点.
- 表观遗传年龄与认知衰退之间的联系需要进一步研究.
研究的目的:
- 调查表观遗传年龄加速与认知表现之间的关联.
- 探索功能性大脑连接作为这种关联中介者的作用.
主要方法:
- 利用DNA甲基化数据来计算表观遗传年龄 (AgeAccelGrim).
- 评估认知功能,包括流体和结晶智能.
- 采用功能磁共振成像 (fMRI) 和基于连接体的预测模型.
主要成果:
- 加速表观遗传年龄的个体在各种认知任务中表现较差.
- 功能性连接,特别是在中间叶和边缘结构中,介导了表观遗传年龄加速和认知之间的联系.
结论:
- 表观遗传衰老对老年人的认知能力和大脑功能产生重大影响.
- 功能性大脑组织在表观遗传衰老和认知衰退之间的关系中起着关键作用.
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