相关实验视频
Updated: Jun 27, 2025

13:00
Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
2.3K
复原病毒衍生的人类蛋白质的受体识别和抗病毒机制
Shashank Khare1, Miryam I Villalba1, Juan C Canul-Tec1
1Fundamental Microbiology and Pathogenicity Unit, CNRS, Université de Bordeaux, IECB, Bordeaux, France.
Nature structural & molecular biology
|April 26, 2024
概括
人类的syncytin-1和suppressyn蛋白与ASCT2受体结合,形成一个. 这种机制揭示了这些胎盘蛋白如何与逆转录病毒相互作用,影响母亲和胎儿的健康.
科学领域:
- 结构生物学是结构生物学.
- 复原病毒研究研究.
- 生殖免疫学 生殖免疫学
背景情况:
- 人类的syncytin-1和suppressyn是对胎盘发育至关重要的逆转录病毒蛋白.
- 这些蛋白质参与细胞融合,并限制某些逆转录病毒感染.
- 它们与ASCT2受体的相互作用是关键的,但人们对其了解甚少.
研究的目的:
- 阐明syncytin-1和suppressyn与ASCT2受体结合的结构机制.
- 了解这些胎盘蛋白如何与逆转录病毒相互作用,并可能抑制逆转录病毒.
- 为胎盘蛋白功能提供高分辨率的结构洞察力.
主要方法:
- 电子显微镜 (cryo-EM) 用于确定复杂的结构.
- 用ASCT2分析syncytin-1和suppressyn的受体结合域.
- 现有的逆转录病毒受体结合域的结构预测.
主要成果:
- 低温EM结构显示syncytin-1和suppressyn结合ASCT2在类似的位置.
- 一个混合β片""稳定了蛋白质受体相互作用.
- 复原病毒结合部位与胎盘蛋白重叠,表明存在竞争机制.
结论:
- 胎盘蛋白和各种逆转录病毒共享一个共同的ASCT2识别机制.
- 结构洞察力解释了syncytin-1和suppressyn如何发挥形态和免疫学作用.
- 这项研究澄清了母胎界面上的逆转录病毒干扰和宿主免疫.
相关概念视频
Retroviruses
12.2K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.2K
Retrovirus Life Cycles
45.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
LTR Retrotransposons
17.5K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
17.5K
Viral Structure
62.1K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.1K
Immune Response Against Viral Pathogens
777
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
777

