患有类风湿性关节炎和肉类症的患者的炎症概况
Mariel Lozada-Mellado1, Luis Llorente2, Andrea Hinojosa-Azaola2
1Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Clinical rheumatology
|April 26, 2024
概括
肌肉质量的丧失,即萨尔科佩尼亚,在类风湿性关节炎 (RA) 患者中很普遍. 较高水平的炎症性细胞因子如IL-1α,IL-6和TNFβ与RA妇女的肉症有关.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 标志着肌肉质量和力量损失的萨科佩尼亚与衰老和慢性疾病有关.
- 类风湿性关节炎 (RA) 涉及慢性炎症,可以加速肌肉恶化和肉类的发展.
- 在RA中 Sarcopenia 与身体残疾,心血管问题,疾病活动和死亡率有关.
研究的目的:
- 为了比较RA患者的炎症概况,有和没有肉症.
- 在RA患者中调查特定细胞因子和肉症之间的关联.
主要方法:
- 一项对165名RA妇女进行的横截面研究.
- 根据欧洲老年人肉症工作组的标准来诊断肉症.
- 测量细胞因子度 (EGF,IL-17,IL-1α,IL-1β,IL-6,TNFα,TNFβ) 和肌酸酶 (CK) 的测量.
主要成果:
- 在研究人群中,肉类的患病率为15.8%.
- 患有肉类症的患者年龄较大 (中位数为59.5岁与50岁),疾病持续时间较长 (中位数为21岁与13岁).
- 在RA患者中观察到显著更高的IL-1α,IL-6和TNFβ度,这些患者患有肉症,经过BMI,年龄和疾病持续时间的调整.
结论:
- 患有皮病的RA患者年龄较大,疾病持续时间较长,炎症性细胞因子水平较高.
- 较高的IL-1α,IL-6和TNFβ水平可能表明RA中的肉症在RA中发挥了作用.
- 这些发现表明,对治疗RA患者的性硬化症有潜在的临床影响.
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