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虹膜组合指数用于诊断女孩中部早期青春期:一个横截面研究

Jie Wang¹, Yongquan Tang¹, Guanyu Chen¹

¹Department of Pediatrics, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, China.

|April 26, 2024

概括

在中部早熟青春期 (CPP) 的女孩中,血清里素水平升高. 虹膜素与基底LH和子宫体积相结合,提供了对女孩中CPP的高度准确的诊断指数.

科学领域:

儿科内分泌学儿科内分泌学
生殖医学生殖医学
生物标志物发现发现

背景情况:

中部早期青春期 (CPP) 涉及女孩的早期性发育.
准确诊断CPP对于适当的管理至关重要.
虹膜素在CPP诊断中的作用需要进一步研究.

研究的目的:

为了评估不同发育状态的女孩的血清素水平.
确定伊丽素在女孩中部早期青春期 (CPP) 的诊断效用.

主要方法:

一项涉及111名女孩的横截面研究 (43名CPP,44名外围PP,24名对照).
收集的数据包括激素水平 (LH,FSH,雌激素,虹膜素),人体测量和盆腔超声波.
女孩是根据GnRH刺激测试进行分类的.

主要成果:

与外围PP和对照组相比,CPP组的血清虹膜素水平显著更高.
虹膜素水平与LH,FSH,子宫体积和骨年龄指标正相关.
血清虹膜蛋白对CPP具有很高的诊断性能 (AUC为0.958,灵敏度为100%,特异性为80.6%).

结论:

在被诊断患有CPP的女孩中,血清里素水平显著升高.
使用虹膜素,基底LH和子宫体积的综合诊断指数显示CPP诊断的精度更高 (AUC 0.994).

关键词:

诊断诊断诊断诊断诊断一个女孩,一个女孩.虹膜虹膜是一种虹膜.盆腔超声波的使用方法过早的青春期过早的青春期

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