柏林幼儿园环境中的SARS-CoV-2血清流行:一个跨部门研究,2021年9月
Julian Bernhard1, Stefanie Theuring1, Welmoed van Loon1
1Institute of International Health, Charité Center for Global Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany.
Children (Basel, Switzerland)
|April 27, 2024
概括
截至2021年9月,SARS-CoV-2血清学在柏林幼儿园发现了高血清活性,儿童显示出最不识别的感染. 在学龄前儿童中,这些无声感染需要考虑准确的COVID-19动态评估.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 了解SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染动态对于公共卫生干预至关重要.
- 幼儿园是由于幼儿之间的密切接触而可能传播病毒的独特环境.
- 追溯的血清学研究可以揭示过去的感染模式,包括无症状或未诊断的病例.
研究的目的:
- 评估与柏林幼儿园相关人员的SARS-CoV-2血清流行情况.
- 为了确定这个队列中以前未被识别的SARS-CoV-2感染的比例.
- 为了调查感染和诸如面具使用之类的行为因素之间的潜在关联.
主要方法:
- 在2021年9月进行了一项横截面的血清学调查,涉及来自12所随机选择的幼儿园的儿童,工作人员和家庭成员.
- 参与者通过采访提供了人口统计信息和COVID-19历史.
- 血液样本使用电化学发光免疫测试 (Roche Elecsys) 分析了SARS-CoV-2特异性抗体 (抗S和抗N).
主要成果:
- 总体SARS-CoV-2血清活性为65.0%,其中52.7%的参与者接种了疫苗.
- 在16.7%的儿童,16.2%的员工和10.4%的家庭成员中发现了以前感染的证据.
- 儿童 (12.5%) 的未诊断感染率最高,感染与面罩使用量减少有关.
结论:
- 截至2021年9月,柏林幼儿园相关队列中的很大一部分表现出SARS-CoV-2血清活性,主要是由于成年人接种疫苗.
- 幼儿园儿童的非疫苗诱导血清阳性和未被识别的感染率最高.
- 在学龄前儿童中沉默的SARS-CoV-2感染的流行需要在幼儿园环境中的流行病学评估中仔细考虑.
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