探索患有便蛋白水平升高的儿童的诊断谱
Angharad Vernon-Roberts1, Olivia Humphrey2, Andrew S Day1
1Department of Paediatrics, University of Otago Christchurch, Christchurch 8011, New Zealand.
Children (Basel, Switzerland)
|April 27, 2024
概括
没有炎症性肠病 (IBD) 的儿童便calprotectin (FC) 的升高通常表明轻度炎症或感染. 重复的FC测试可以帮助区分诊断,指导进一步的调查和管理.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床诊断 临床诊断 临床诊断
- 炎症性肠道疾病研究研究
背景情况:
- 便中的calprotectin (FC) 是肠道炎症的一个关键生物标志物.
- 关于在没有确定的炎症性肠病 (IBD) 的儿童中增加FC的意义的研究有限.
研究的目的:
- 调查4-17岁未被诊断为IBD的儿童中异常FC水平的原因和临床相关性.
- 为了分层异常的FC结果,并分析相关的症状和诊断发现.
主要方法:
- 在新西兰南岛对患有FC检测异常的儿童进行了回顾性研究.
- FC的分层结果在范围 (51-249,250-499,500+μg/g) 中.
- 收集有关症状,诊断测试和后续诊断的数据.
主要成果:
- 310名儿童患有异常FC;中位数年龄为12.9岁,55%为女性.
- 大多数异常FC水平 (71%) 在轻度范围内 (51-249μg/g).
- 患有FC500+μg/g的儿童经常被诊断患有传染性腹或IBD;警报症状没有区分.
结论:
- 没有IBD的儿童的高FC通常反映了轻度炎症或感染,其水平低于显著的粘膜炎症的典型值.
- 血小板计数,超声波和结肠镜异常在被诊断为IBD的儿童中更为常见.
- 重复的FC检测对于区分诊断非常有价值,尤其是在区分IBD与其他导致FC升高的原因时.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
342
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
342
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Assessment of the Rectum and Anus
205
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
205
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
157
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
157
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
115
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
115


