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关于PEO和PEO-PPG功能化色素纳米颗粒用于药物输送的结构和分子特性

Rejeena Jha¹, Hyrum Harlow¹, Mourad Benamara²

¹Department of Physics, Astronomy, and Materials Science, Missouri State University, Springfield, MO 65804, USA.

Bioengineering (Basel, Switzerland)

|April 27, 2024

概括

基托纳米颗粒 (CS-NP) 在纳米医学中显示出潜力. 将CS-NP与PEO-PPG功能化显著增加了它们的结晶性,影响了它们在药物输送应用中的性能.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

素纳米颗粒 (CS-NP) 是多功能纳米载体,用于各种纳米医学应用.
了解CS-NP的结构和形态特性对于优化其药物递送能力至关重要.

研究的目的:

通过离子凝合成的素纳米粒子 (CS-NP) 的结构,形态和分子特征的研究.
评估用聚乙烯氧化物 (PEO) 和PEO-聚乙烯甘醇 (PPG) 功能化对药物输送中CS-NP特性的影响.

主要方法:

在不同度 (0.251.0% w/v) 中使用离子凝合成CS-NP.
使用PEO和PEO-PPG双块共聚合物的1.0% w/v CS-NP的功能化.
使用传输电子显微镜 (TEM),X射线衍射 (XRD) 和富里埃变换红外光谱 (FTIR) 的表征.

主要成果:

TEM成像揭示了CS-NP,其平均尺寸范围为11.314.8 nm.
XRD和TEM表示半晶体结构,晶体性受到功能化的影响.
PEO-PPG功能化显著增加了CS-NP晶度,而PEO单独没有影响. CS/TPP比率没有影响结晶度.
FTIR证实了TPP的结合和在更晶体的CS-NP中增加的结合.

结论:

该研究阐明了合成的CS-NP的结构和形态特性.
与PEO-PPG的功能化增强了CS-NP的结晶性,为量身定制的药物递送系统提供了潜力.
这些发现有助于合理设计生物医学应用的基托基纳米载体.

关键词:

里埃变换红外光谱法红外光谱法在X射线中,X射线的衍射效果是不同的.基托桑纳米颗粒基托桑纳米颗粒聚合物的功能化.结构属性结构属性传输电子显微镜的使用

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