由于线圈旋转而引起的跨膜磁刺激对皮层激活的变化不能归因于肌激活
Marco Mancuso1, Alessandro Cruciani2,3, Valerio Sveva4
1Department of Human Neuroscience, University of Rome "Sapienza", Viale dell'Università 30, 00185 Rome, Italy.
Brain sciences
|April 27, 2024
概括
通过电脑学 (TMS-EEG) 优化通过旋转线圈来减少肌肉人工物来优化横磁刺激,改变了大脑信号的测量. 精心定位线圈对于准确的TMS-EEG研究至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 信号处理 信号处理
背景情况:
- 经磁刺激与脑电图 (TMS-EEG) 结合,对于在各种条件下调查大脑动态至关重要.
- 在TMS-EEG期间的肌激活可以掩盖真正的神经信号,需要先进的预处理.
- 线圈旋转对TMS-EEG信号完整性的影响仍然不清楚,这是一种最大限度地减少肌肉工件的方法.
研究的目的:
- 为了比较使用标准线圈定向获得的TMS-EEG数据与优化以最大限度地减少肌肉激活的定向.
- 为了评估线圈旋转对关键TMS-EEG指标的影响:TMS引起的电位 (TEP),TMS相关的光谱扰动 (TRSP) 和试验间阶段集群 (ITPC).
- 评估这些影响在两个不同的预处理管道 (ICA和SSP-SIR) 的一致性.
主要方法:
- 使用了两个线圈方向:标准 (M1标准) 为最佳的电机唤起潜力和旋转 (M1emg) 来减少电肌学 (EMG) 文物.
- 对于这两种条件,TEP,TRSP和ITPC都被计算出来.
- 数据使用独立组件分析 (ICA) 和信号空间投影与源信息重建 (SSP-SIR) 管道进行处理.
- 使用一致性相关系数 (CCC) 来量化条件之间的信号相似性.
主要成果:
- 与M1标准相比,在M1emg条件下观察到TEP,TRSP和ITPC的显著减少.
- 一个低于预期的一致性相关系数 (CCC) 表明了两种条件之间的显著差异.
- 这些发现在ICA和SSP-SIR预处理管道中一致.
结论:
- 虽然旋转TMS线圈可以有效地减少肌人工物,但它显著改变了测量的TMS-EEG信号.
- 研究人员必须仔细考虑权衡,并根据他们的具体实验目标和预处理方法量身定制线圈定位策略.
- 线圈方向的选择会影响从TMS-EEG中获得的大脑动态的解释.
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