感染SARS-CoV2-A的个体肺栓塞的危险因素 单中心回顾性研究
Alexandra Herlo1, Adelina Raluca Marinescu1, Talida Georgiana Cut1
1Department XIII, Discipline of Infectious Diseases, Victor Babes University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Biomedicines
|April 27, 2024
概括
COVID-19患者患有肺栓塞 (PE) 和其他血栓事件的高风险,这些事件与死亡率增加有关. 肥胖,糖尿病和脂质不良症在这些患者中显著增加PE风险.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染与高发生率的血栓事件有关.
- 血栓栓塞,高凝血和细胞因子释放有助于COVID-19患者的多器官衰竭.
研究的目的:
- 研究COVID-19患者肺栓塞 (PE) 的发生率和危险因素.
- 在COVID-19队列中分析并发症和动脉血栓事件之间的关联.
主要方法:
- 在420名COVID-19患者的回顾性单中心研究中.
- 患者分为对照 (319) 和肺栓塞 (101) 组.
- 分析了人口统计数据,实验室发现和并发症.
主要成果:
- 24%的COVID-19患者患有肺栓塞;21.42%的死亡率.
- 与年龄相关的动脉血栓事件,心血管疾病,白细胞,D-二次体和专蛋白.
- 肥胖 (OR 2.8),糖尿病 (OR 3.3) 和脂质失调 (OR 3.6) 与PE有很强的相关性.
结论:
- 患有严重疾病的COVID-19患者表现出显著的动脉血栓事件发生率.
- 这些血栓事件与较差的生存率有关.
- 诸如肥胖,糖尿病和脂质失调等并发症是COVID-19中PE的关键风险因素.
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