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在患有牛皮关节炎的患者中,循环中的CD14+单细胞增加,其亡活动受损

Shang-Hung Lin^1,2,3, Chung-Yuan Hsu^2,3,4, Sung-Chou Li^5,6,7

¹Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

|April 27, 2024

概括

牛皮关节炎患者表现出增加的外围CD14+单细胞与受损的亡. 单细胞的编程细胞死亡中的这种缺陷可能会导致牛皮关节炎的关节炎症和骨质细胞激活.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
分子生物学分子生物学

背景情况:

牛皮关节炎 (PsA) 是一种慢性炎症状况,影响关节.
骨质细胞激活驱动了PsA关节中观察到的骨解效应.

研究的目的:

调查PsA患者与健康对照的外围CD14+单细胞中的差异性基因表达.
确定PsA中单细胞功能障碍背后的分子机制.

主要方法:

从PsA患者 (n=15) 和健康对照 (n=15) 中分离了外围CD14+单细胞.
流细胞测量用于对亡的评估 (附件V).
微阵列分析用于基因表达特征 (GEO加入:GSE261765) 和PCR验证.

主要成果:

与HC相比,PsA患者的外围CD14+单细胞数量较高.
在PsA患者的CD14+单细胞中,亡信号通路显著受损.
在PsA单细胞中,甲素L的相对表达显着较低.

结论:

在PsA患者中增加了外围CD14+单细胞数量和受损的细胞灭亡.
这种单细胞功能障碍可能会促进巨细胞成熟和骨质细胞激活.
CD14+单细胞对亡的抵抗可能会导致PsA的活跃关节炎症.

关键词:

在CD14+单细胞中.灭症 (apoptosis) 是一种死亡的过程.卡瑟普辛 L L L 的情况.骨质结晶体的骨质细胞.牛皮关节炎牛皮关节炎

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