与SARS-CoV-2相关的嗅觉功能障碍:解剖结果,组织病理学和病毒RNA和ACE2表达在嗅觉泡中的评估
Marco Dell'Aquila1,2, Concetta Cafiero3,4, Alessandra Micera5
1Anatomic Pathology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Biomedicines
|April 27, 2024
概括
虽然COVID-19会引起无氧化症,但SARS-CoV-2 RNA在嗅觉球体中没有,这表明有间接机制. 需要进一步的研究,以了解和减轻病毒对嗅觉球体的损伤.
科学领域:
- 神经学 神经学
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 由于COVID-19大流行,造成了广泛的健康问题,包括厌氧 (嗅觉丧失).
- 导致SARS-CoV-2引起的嗅觉功能障碍背后的确切机制尚不清楚,关于病毒神经变的假设仍在争论中.
研究的目的:
- 为了调查死尸肺和嗅球组织中SARS-CoV-2和ACE2受体转录的存在.
- 为了将分子发现与COVID-19患者的组织病理特征相关联.
主要方法:
- 实时RT-PCR被用于检测SARS-CoV-2和ACE2RNA在25个尸体肺和嗅球组织中.
- 进行了组织学染色,并与分子数据进行比较.
主要成果:
- 在23/25个肺样本中检测到SARS-CoV-2RNA,但在所有嗅球样本中没有检测到.
- 所有检查的组织中都存在ACE2受体RNA,与嗅觉灯泡相比,肺组织中的表达更高.
结论:
- 与COVID-19相关的厌氧症可能不仅仅是由嗅球直接感染SARS-CoV-2引起的.
- 嗅球中的SARS-CoV-2神经病变需要进一步调查,以了解和解决相关的损害.
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