RNARNA

Wenyuan He1, Denise D Belsham1,2

  • 1Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Biomedicines
|April 27, 2024
PubMed
概括

RNA结合蛋白 (RBPs) 在分类细胞微RNA (miRNAs) 进行分泌或保留方面发挥着关键作用. RBP图案预测了细胞特异的miRNA定位,这对于开发有效的小RNA疗法至关重要.

相关概念视频

MicroRNAs01:22

MicroRNAs

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Types of RNA01:23

Types of RNA

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Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
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RNA Stability01:53

RNA Stability

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Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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