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Updated: Jun 23, 2026

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从T细胞生成的人工细胞外囊,使用不同的诱导技术

Ekaterina A Zmievskaya1, Sabir A Mukhametshin1, Irina A Ganeeva1

  • 1Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.

Biomedicines
|April 27, 2024
PubMed
概括

研究人员探索了增加细胞外囊泡 (EV) 产生用于无细胞治疗的方法. 超声波与T细胞激活相结合,显著提高了EV产量和治疗性蛋白质含量.

关键词:
在T细胞,T细胞.人工囊泡的人工囊泡细胞外囊泡中的细胞外囊泡.超声波的超声波处理方法囊泡诱导诱导是什么意思

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.