酸乙醇胺通过调节小猪肠道杯细胞的粘液分泌来改善产后生长迟缓
Nan Wang1,2, Chengming Wang1,2, Ming Qi1,2
1College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Animals : an open access journal from MDPI
|April 27, 2024
概括
酸乙醇胺 (PE) 补充剂改善了产后生长迟缓 (PGR) 的小猪的生长. PE增强了肠道屏障功能,增加了MUC2表达,并促进了杯状细胞的分化,缓解了PGR症状.
科学领域:
- 新生儿营养新生儿营养
- 胃肠病学 胃肠病学
- 动物科学动物科学
背景情况:
- 酸乙醇胺 (PE) 是新生儿发育的重要脂.
- 产后生长迟缓 (PGR) 对新生儿生长和肠道健康产生负面影响.
- 改善肠道屏障功能是解决PGR的一个关键策略.
研究的目的:
- 调查外源性甲基乙醇胺 (PE) 对新生猪产后生长迟缓 (PGR) 的影响.
- 为了确定PE补充是否可以改善PGR的小猪的肠道屏障功能.
- 阐明PE影响肠道健康和生长的机制.
主要方法:
- 32只新生猪被分为对照组和PE补充组,分为正常出生体重 (NBW) 和PGR亚组.
- 在哺乳期和哺乳期后给予PE.
- 分析了肠道形态,MUC2表达,杯状细胞分化 (Spdef) 和内分泌网膜压力标志物.
主要成果:
- 与对照组相比,PE补充剂改善了PGR猪仔的生长性能.
- PGR猪仔表现出受损的肠道形态,PE通过增加的高度与密室深度的比率和杯细胞数量来部分恢复.
- PE增加了MUC2表达和SpdefmRNA水平,同时降低了PGR小猪体内质内膜的压力标志物.
结论:
- 外源甲基乙醇胺 (PE) 有效缓解新生猪的产后生长迟缓 (PGR).
- 通过促进杯细胞分化和MUC2表达,PE增强了肠道屏障功能.
- 补充PE是改善新生儿生长和肠道健康的有希望的策略.
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