怀孕中的COVID-疫苗:产后前9个月的孕产妇和新生儿反应
Alice Proto1, Stefano Agliardi2, Arianna Pani3
1Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milan, Italy.
Biomolecules
|April 27, 2024
概括
从SARS-CoV-2疫苗接种中产生的母体抗体有效地转移到新生儿身上. 这些保护性抗体在婴儿生命的前九个月内显示出显著的耐用性.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿的医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在怀孕期间确立了COVID-19疫苗接种的安全性.
- 关于母体抗体转移和婴儿疫苗接种后抗体持久性的数据有限.
研究的目的:
- 为了评估母体通过胎盘传播的抗体.
- 评估9个月以下新生儿的抗体动力学.
- 为了将抗体水平与母亲的疫苗接种状态和婴儿结果相关联.
主要方法:
- 对98名接种疫苗的孕妇和103名新生儿进行前性队列研究.
- 在出生和随访 (3,6,9个月) 时测量的抗体水平.
- 母婴/新生儿抗体水平和接种疫苗后的时间的相关性分析.
主要成果:
- 在出生时母体和新生儿抗体水平之间存在显著的正相关性.
- 抗体水平在9个月内下降,受孕妇接种疫苗剂量数量的影响.
- 从受感染的双体和母乳养的婴儿中观察到较慢的抗体下降.
结论:
- 母亲的抗SARS-CoV-2抗体在胎盘中有效地转移.
- 在婴儿早期,新生儿的抗体表现出显著的持久性.
- 母乳可能有助于抗体转移和婴儿保护.
更多相关视频
05:13Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
187
13:00Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
Published on: July 31, 2021
3.6K
相关概念视频
Development of Immunocompetence
305
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
305
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Vaccinations
44.4K
Overview
44.4K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
276
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
276
Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
