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通过一般的表型查方法来选择素替代品,以检测受体激动剂的受体

Tao Wang1,2, Xixi Chen1,2, Guang Yang1

  • 1Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.

Biomolecules
|April 27, 2024
PubMed
概括

研究人员开发了一种名为生物受体激活依赖细胞存活 (BRADS) 的新选方法,以找到有用的生物分子. 这种具有成本效益的技术成功地确定了人体瘦素替代物,证明了它对各种生物受体的潜力.

关键词:
生物受体激活依赖细胞存活率 (BRADS)细胞因子替代品的替代物高通量选的高通量选现型查 现型查 现型查作为受体激活剂的受体激活剂.

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Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
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