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通过活性站点醇化剂对组织转质氨酶的 conformational 调制:大小并不重要

Pauline Navals1, Alana M M Rangaswamy1, Petr Kasyanchyk1

  • 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Biomolecules
|April 27, 2024
PubMed
概括

向转谷氨酶2 (TG2) 的小分子抑制剂不需要固体质量来阻止其G蛋白活性. 即使是最小的抑制剂也能有效地将TG2锁定在无活性构造中,防止瓜诺辛三酸盐 (GTP) 结合.

关键词:
这是一种G蛋白质.合规调制是一种调制.无法逆转的抑制剂.有针对性的共价抑制剂.转谷氨酸酶2的使用转氨酸酶抑制剂的使用

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