肝炎C相关的肝细胞癌,仍然是一个相关的病因学超出肝炎C感染治愈
Elena Vargas-Accarino1, Mónica Higuera1, María Buti1,2,3,4
1Liver Diseases Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
Cancers
|April 27, 2024
概括
与酒精有关的肝病是肝细胞癌 (HCC) 的主要原因,即使有可用的C型肝炎病毒 (HCV) 抗病毒疗法. 公共卫生政策对于制饮酒和预防肝癌至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 全球变化影响肝癌的原因,包括疫苗接种,抗病毒治疗和脂肪肝疾病的患病率.
- 肝癌病因的不断变化需要更新的流行病学研究.
研究的目的:
- 为了调查新的肝细胞癌 (HCC) 诊断的病因因素.
- 从2019年到2022年,分析一个学术中心内的肝癌原因的趋势.
主要方法:
- 追溯性研究设计.
- 对352名被诊断患有HCC的连续患者的分析.
- 评估病因因素,患者人口统计,BCLC阶段和肝硬化患病率.
主要成果:
- 与酒精有关的肝病是HCC的主要病因 (33.3%).
- 肝炎C (HCV) 感染是第二个最常见的原因 (30.7%).
- 在HCC病因和患者人口统计,BCLC阶段和肝硬化之间观察到显著的关联.
结论:
- 尽管可以获得抗病毒疗法,但HCV仍然是HCC的主要原因.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关的HCC在该地区的流行率较低,与全球趋势相比.
- 强有力的公共卫生政策对于减少酒精消费至关重要,这是肝病和肝癌的主要驱动因素.
更多相关视频
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.9K
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.2K
相关概念视频
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
