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前列腺癌患者的前列腺组织微生物组:系统性审查
Daniela F Ward Grados1, Onuralp Ergun1, Carly D Miller1
1Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
Cancers
|April 27, 2024
概括
前列腺微生物组可能与前列腺癌 (PCa) 有关,并发现了特定细菌和病毒的潜在关联. 然而,目前的数据有限,需要进一步的研究来得出关于PCa病变的最终结论.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 前列腺微生物组在前列腺癌 (PCa) 发展中的作用正在研究中.
- 现有的研究缺乏关于PCa与健康前列腺组织的特定微生物关联的共识.
研究的目的:
- 系统地审查和比较PCa患者和健康对照的前列腺组织微生物组.
- 为了确定与PCa病变发生的潜在微生物关联.
主要方法:
- 在MEDLINE,Embase和Scopus数据库中进行系统的文献搜索.
- 由两个独立的,盲目的评论员对文章进行选.
- 包括比较PCa患者和良性对照的前列腺组织微生物组的研究.
主要成果:
- 他们注意到PCa与增加的*Propionibacterium acnes*,*Mycoplasma genitalium*,以及病毒家族*Herpesviridae*和*Papillomaviridae*之间的潜在关联.
- 由于难以获得未受污染的样本,缺乏健康的对照,多样化的方法和不一致的生物选择,在数据解释方面存在重大挑战.
结论:
- 目前的证据表明前列腺微生物组与PCa之间可能存在联系,但无法得出确定的结论.
- 需要使用标准化方法和适当的控制进行进一步的研究,以阐明前列腺微生物组在PCa病变发生中的作用.
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