Th2细胞与辐射后瘤复发有关
Mohamed K Abdelhakiem1, Riyue Bao2, Phillip M Pifer1
1Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Cancers
|April 27, 2024
概括
高Th2免疫细胞透预测辐射后HPV/p16阴性头支状细胞癌 (HNSCC) 的结果会更差. 这种免疫反应与DNA修复途径和抵抗癌症治疗有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
背景情况:
- 辐射疗法是头部和部状细胞癌 (HNSCC) 的首要治疗方法.
- 与HPV/p16阳性瘤相比,HPV/p16阴性HNSCC的结果较差,辐射抵抗性增加.
- 了解HPV/p16阴性HNSCC的免疫功能对于识别辐射耐药性和预后生物标志物的机制至关重要.
研究的目的:
- 分析免疫细胞透和HPV/p16阴性HNSCC.患者在辐射后的患者结果之间的关系.
- 确定与辐射耐药性和局部区域复发 (LRR) 相关的潜在免疫生物标志物.
- 阐明这种患者群体中辐射抵抗的基础机制.
主要方法:
- 利用RNA测序 (RNAseq) 基因表达数据从发现 (94名患者) 和验证 (97名患者) 队列中获得瘤免疫透物.
- 在独立验证队伍中,检查的免疫细胞类型与发现队列的结果显著相关.
- 对与Th2细胞透相关的基因进行了途径分析.
主要成果:
- 在发现和验证队列中,高Th2免疫细胞透与增加的局部区域复发 (LRR) 有积极的关联.
- 在CREBBP/EP300和CASP8中发生的瘤突变与Th2透率的增加显著相关.
- 途径分析显示,Th2透与抑制的抗瘤免疫相关,并激活了与BRCA1相关的DNA损伤修复.
结论:
- Th2免疫透体富含HPV/p16阴性HNSCC,并与较差的结果和特定的瘤突变有关.
- 这些发现表明,Th2免疫反应可能通过抑制抗瘤免疫力和激活DNA修复途径来促进辐射抵抗.
- Th2透代表了HPV/p16阴性HNSCC患者用放射治疗的潜在预后生物标志物.
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