黄素作为一种多功能香料成分,用于治疗人类精神障碍:当前的临床研究和生物可用性问题
Maria Spanoudaki1,2, Sousana K Papadopoulou1, Georgios Antasouras3
1Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.
Life (Basel, Switzerland)
|April 27, 2024
概括
黄素在治疗抑郁症,焦虑和压力方面表现有前途,但由于生物可用性较低,其在人类中的有效性受到限制. 像纳米配方这样的先进配方显著增强了黄素的功效.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 抑郁症,焦虑和压力等精神障碍对全球健康构成重大负担.
- 植物衍生化合物越来越多地被用于心理健康治疗,但生物可用性挑战往往限制了疗效.
- 黄素是一种天然化合物,因其对心理健康的潜在治疗作用引起了人们的兴趣.
研究的目的:
- 审查使用黄素治疗精神障碍的新方法.
- 批判性地分析黄素的生物可用性和提高它的策略.
- 总结目前关于黄素在心理健康治疗中的有效性和局限性的证据.
主要方法:
- 科学文献的全面叙事审查.
- 专注于研究黄素对精神疾病的疗效和生物利用性.
- 对现有的研究和配方技术进行批判性分析.
主要成果:
- 黄素显示出针对各种精神疾病的显著潜力,包括抗焦虑,抗抑郁和抗压力作用.
- 口服生物可用性较低是黄素治疗应用的一个主要限制.
- 制药创新,如纳米配方,脂质体输送和与 piperine 或 galactomannosides 结合,有效地提高了黄素的生物可用性和可溶性.
结论:
- 黄素显示出对心理健康有前途的治疗性质,但对人类的研究是有限的和异质的.
- 进一步的临床研究至关重要,以确定最佳的黄素配方,剂量和治疗持续时间.
- 库尔库明纳米配方和Theracurmin显示出最有前途的作为高度生物可用性的未来临床研究在心理健康的选择.
相关概念视频
Taste Buds and Receptors
1.9K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
1.9K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
121
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
121
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331


