在COVID-19大流行中的Delta变异:基于疫苗接种状态的临床结果的比较研究
Damiana-Maria Vulturar1, Liviu-Ștefan Moacă1, Maria Adriana Neag2
1Department of Pneumology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania.
Journal of personalized medicine
|April 27, 2024
概括
COVID-19疫苗显著降低了严重疾病,重症监护室 (ICU) 的入院率和住院患者的死亡率. 疫苗接种提供了针对SARS-CoV-2感染的严重后果的实质性保护.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19流行病的持续,SARS-CoV-2的三角洲变种带来了独特的挑战.
- 了解疫苗接种对三角洲变种感染的影响至关重要.
研究的目的:
- 评估COVID-19疫苗接种对感染SARS-CoV-2德尔塔变种的患者严重结局的有效性.
- 为了比较接种疫苗和未接种疫苗的患者之间的临床特征和结果.
主要方法:
- 多层次的逻辑回归分析,对197名住院的Delta变种患者进行了多层次的逻辑回归分析 (44名接种疫苗,153名未接种疫苗).
- 患者人口统计数据的比较,CT肺部参与,帕多瓦分数,氧和,通风需求,动脉血液气体 (ABG) 动态,ICU入院和死亡率.
主要成果:
- 未接种疫苗的患者对严重感染的倾向明显更高 (p < 0.05).
- 在未接种疫苗的组中观察到肺部感染率,氧气需求,ICU入院率和死亡率的增加.
结论:
- COVID-19疫苗在预防严重疾病方面表现出相当大的有效性.
- 接种疫苗显著降低了感染德尔塔变种的住院患者的ICU入院率和死亡率.
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