生物膜分解中的局部剂:系统性审查和元分析
Alessia Pardo1, Vera Fiorini1, Alessandro Zangani1
1Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37124 Verona, Italy.
Journal of clinical medicine
|April 27, 2024
概括
在非手术性牙周治疗期间,硫化基凝显著改善了探针口袋深度的减少. 由于生物膜破坏局部剂的证据有限,需要进一步研究.
科学领域:
- 牙周病学 牙周病学
- 微生物学 微生物学
背景情况:
- 非手术性牙周治疗 (NSPT) 旨在破坏下膜生物膜.
- 在NSPT中辅助局部药物的有效性需要评估.
研究的目的:
- 在NSPT期间评估各种局部剂在生物膜分解中的有效性.
- 为了比较NSPT带有和没有局部药物的牙周治疗结果.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 包括11项研究 (10项RCT,1项回顾性分析) 与386名参与者.
- 分析探测口袋深度,临床附着水平,出血指数,斑块指数,牙衰退和微生物学参数.
主要成果:
- 分析显示,探测口袋深度的统计显著减少 (WMD: -0.37;95% CI: -0.62至 -0.12),有利于硫化凝.
- 异质性 (I2:79%) 表明研究之间存在差异.
- 主要结局包括探测口袋深度 (PPD),临床附着水平 (CAL) 和出血指数.
结论:
- 硫酸基凝在治疗后3-6个月检测口袋深度减少时显示出具有统计学意义的好处.
- 目前的科学证据是有限的和异质的.
- 需要进一步进行高质量的随机临床试验,以确认研究结果并探索其他局部药物.
相关概念视频
01:23Hand hygiene
3.2K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.2K
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
823
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
823