在COVID-19患者的自主功能和巴罗反射控制被送往重症监护室的患者
Francesca Gelpi1, Maddalena Alessandra Wu2,3, Vlasta Bari1,4
1Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
与非COVID-19患者相比,严重病情的COVID-19患者表现出保存的巴罗反射控制. 然而,自主和巴罗反射标记在两组中都不能预测存活率,这限制了它们在死亡风险分层中的使用.
科学领域:
- 生理学 生理学 生理学
- 关键护理医学 关键护理医学
- 心血管监管 监管心血管系统
背景情况:
- 自主功能和巴罗反射控制可能会影响2019年新冠肺炎 (COVID-19) 患者在重症监护室 (ICU) 的生存率,而不是那些没有 (非COVID-19) 的患者.
- 了解这些生理机制对于改善重症患者死亡风险分层至关重要.
研究的目的:
- 为了比较重症COVID-19和非COVID-19患者之间的自主和巴罗反射控制机制.
- 评估这些标记在预测ICU生存结果中的有用性.
主要方法:
- 从心脏周期 (HP) 和静心动脉压 (SAP) 的可变性评估了自主和巴罗反射控制标志物.
- 测量是在17名COVID-19和33名非COVID-19患者的休息状态和修改头部向上倾斜 (MHUT) 期间进行的.
- 患者被分为幸存者 (SURV) 或非幸存者 (非SURV).
主要成果:
- 无论是COVID-19还是非COVID-19组,都显示出类似的阴道和交感控制标记.
- 与COVID-19患者相比,非COVID-19患者在MHUT期间的巴罗反射灵敏度较低,HP-SAP关联减少.
- 在这两组患者中,没有自主或巴罗反射标记有效地区分了幸存者和非幸存者.
结论:
- 与非COVID-19患者相比,COVID-19患者表现出更多的保全巴罗反射控制.
- 尽管存在差异,但自主和巴罗反射功能标志物在这些ICU人群中对分层死亡风险无效.
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