对心血管疾病的风险因素和修饰因素 异卵性家族性高胆固醇血症患者的心血管疾病评估
Richard Malone1, Sarah Savage2, Vivion Crowley2
1School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland.
一半的异位家族高胆固醇血症 (HeFH) 患者面临非常高的心血管疾病 (CVD) 风险. 识别额外的风险修饰因素,如家族病史,进一步提高了这种风险,影响了治疗机会.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 在异构性家族性高胆固醇血症 (HeFH) 中,心血管疾病 (CVD) 风险通常使用常规因素进行评估.
- 除了传统因素之外,额外的CVD风险修饰因素对于准确的风险分层和指导新疗法至关重要.
- 这项研究描述了HeFH患者在脂质诊所中的特征,重点关注传统的风险因素和新型风险修饰剂.
研究的目的:
- 在脂质临床队列中识别和描述传统的心血管疾病风险因素和风险修饰因素.
- 在风险因素和修饰因子方面,将HeFH患者与没有HeFH患者进行比较.
- 评估风险修饰因子对HFH患者心血管疾病风险分层的影响.
主要方法:
- 一项为期六个月的连续成人患者的研究,这些患者参加了一家专业的脂质诊所.
- 数据收集包括人口统计,临床特征,风险因素,风险修饰因子 (根据ESC/EAS指南),生化资料和遗传测试.
- 将HeFH患者与其余队列的患者进行比较.
主要成果:
- 在370名总患者中,发现了98名HeFH患者 (26%).
- 52%的HeFH患者由于存在的风险因素被归类为心血管疾病风险非常高的患者.
- 风险修饰因素占主导地位 (73%),特别是早产心血管疾病 (56%),肥胖 (28%) 的家族史,久坐不动的生活方式 (13%) 和严重的精神疾病 (12%) 的风险修饰因素.
- 与非HeFH患者相比,HeFH患者的高血压较少,但与非HeFH患者相比,早期心血管疾病的家族史更多.
结论:
- 大约一半的HeFH患者被归类为心血管风险非常高的患者.
- 结合风险修饰剂,特别是早发心血管疾病的家族史,进一步提高了非常高风险的分类.
- 这些发现可能会影响HeFH新型治疗方案的临床应用和可访问性.
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