与先前尾炎相关的结肠癌率升高:基于德国全科医院数据的回顾性队列研究
Susann Steffes1, Karel Kostev2, Jörn M Schattenberg1,3
1Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Journal of clinical medicine
|April 27, 2024
概括
尾炎可能会增加结肠癌的风险,特别是在年轻男性中. 建议在尾炎后一年内对18-50岁及60岁以上的个人进行早期查,如结肠镜检查或便检查.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 尾炎和结肠癌发病率之间的联系尚不清楚,之前的研究产生了不一致的结果.
- 缺少德国关于尾炎后结肠癌风险的基于人口的数据.
- 这项研究解决了关于尾炎和随后的结肠癌之间的关联的德国人口数据的需求.
研究的目的:
- 调查尾炎与德国人口中结肠癌发病率之间的关联.
- 将尾炎患者的结肠癌发病率与匹配的对照组进行比较.
主要方法:
- 追溯队列研究的设计.
- 包括49,790名患者,根据年龄,性别,指数年,咨询频率和并发症进行匹配.
- 用物流回归分析来评估这种关联.
主要成果:
- 在长达15年的随访期间,尾炎患者的结肠癌发病率较高 (1.04%) 与对照组 (0.60%) 相比.
- 大约36.4%的结肠癌病例发生在尾炎后的六个月内.
- 发现了显著的关联,特别是在男性和18-30岁和41-50岁的年龄组,与高危险比率.
结论:
- 这项研究表明,尾炎与德国结肠癌发病率增加之间存在显著的关联.
- 建议包括在尾炎后12个月内提供查测试 (结肠镜或便测试).
- 特别建议对年龄在18-50岁和60岁以上,一般健康状况良好的人进行查.
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