儿童和成人慢性支气管炎:定义,病理生理学,患病率,危险因素和后果
Jingwen Zhang1, Danielle F Wurzel1,2, Jennifer L Perret1,3
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3053, Australia.
Journal of clinical medicine
|April 27, 2024
概括
儿童慢性支气管炎 (CB),称为长期细菌性支气管炎 (PBB),可以持续到成年. 本综述探讨了CB定义的演变,风险因素及其与其他慢性呼吸道疾病的联系.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
背景情况:
- 慢性支气管炎 (CB) 的定义已经演变,使其对其原因和影响的理解变得复杂化.
- 儿童CB,称为长期细菌支气管炎 (PBB),涉及持续的呼吸道炎症,通常是由于细菌感染.
- 儿童CB可能会持续到成年期,并与喘,支气管切除和COPD有关.
研究的目的:
- 审查目前关于定义,病理生理学,危险因素和慢性支气管炎在儿童和成年人的后果演变的证据.
- 要突出风险因素,儿童CB,成人CB和其他慢性呼吸系统疾病之间的复杂相互作用.
- 强调需要进行纵向研究,以澄清CB在整个生命周期中的自然史.
主要方法:
- 对有关慢性支气管炎的现有文献进行系统审查.
- 对研究的分析,重点关注定义,病因学和临床结果.
- 关于从童年 PBB 过渡到成年 CB 和相关呼吸道疾病的证据综合.
主要成果:
- 在儿童 (PBB) 和成年人中,CB呈现不同,具有不同的病因因素.
- 儿童CB的一个子集进展到成人CB,增加其他慢性呼吸道疾病的风险.
- 关于CB进展及其长期后果的纵向数据有限.
结论:
- 了解慢性支气管炎的终身发展轨迹需要进一步进行全面的纵向研究.
- 早期识别和管理PBB可能对于预防长期呼吸道发病率至关重要.
- 该审查综合了当前的知识,确定了了解CB的自然历史的差距.
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