末期慢性病 (CKD) 的人群中的脆弱性骨折:患者相关的和CKD相关的因子分析 - 一个单一中心的经验
Domenico De Mauro1,2,3, Gianmarco De Luca4, Silvia Marino1,2
1Orthopedics and Traumatology Unit, Department of Ageing, Orthopedics and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
吸烟和更长的透析时间增加了慢性病 (CKD) 患者的脆弱性骨折风险. 针对这些因素的早期干预可以帮助预防骨折并改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 整形外科 整形外科 整形外科
- 老年病的医生 老年病的医生
背景情况:
- 慢性病 (CKD) 是一个全球性的健康问题,具有重要的矿物质和骨疾病并发症.
- 脆弱性骨折是CKD相关的矿物和骨疾病的严重并发症,影响生存和生活质量.
- 确定患者和CKD相关的风险因素对于开发CKD患者脆弱性骨折的预防策略至关重要.
研究的目的:
- 分析患有慢性病的个体中脆弱性骨折的患者相关风险因素.
- 确定导致脆弱性骨折发生率的CKD相关风险因素.
- 在CKD人群中为脆弱性骨折制定有针对性的预防措施.
主要方法:
- 这是一项回顾性,单中心的观察性研究,利用了2021-2023年患者数据.
- 包括与患者相关的和与CKD相关的注册表数据,并补充了关于创伤病史的患者访谈.
- 进行了后勤回归分析,以评估独立和依赖变量之间的关联.
主要成果:
- 该研究包括84名末期CKD患者 (平均年龄为64.3岁,58.3%为男性).
- 吸烟习惯被确定为下肢脆弱性骨折的重要危险因素 (p=0.011).
- 慢性瘤诊断后的时间增加 (p=0.021) 和透析开始 (p=0.001) 与较高的脆弱性骨折发生率成正比.
结论:
- 与患者相关的吸烟习惯显著增加了CKD患者下肢脆弱性骨折的风险 (p <0.05).
- 与CKD相关的因素,特别是自诊断和透析开始以来的更长时间,与骨折风险增加直接相关.
- 结合模和维生素D类比治疗显示,潜在的减少近端股骨骨折.
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