生物标志物和PET成像可以预测腹腔大动脉瘤生长率吗?
Samuel Bruls1, Lucia Musumeci1,2, Audrey Courtois2
1Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, 4000 Liège, Belgium.
Journal of clinical medicine
|April 27, 2024
概括
像C反应蛋白 (CRP) 这样的循环生物标志物在患有腹腔大动脉动脉瘤 (AAA) 和PET阳性发现的患者中升高. 虽然PET阳性没有预测AAA的快速增长,但CRP水平升高确实如此,提供了预后价值.
科学领域:
- 心血管医学 心血管医学
- 医疗成像医学成像
- 生物标志物发现发现
背景情况:
- 腹腔大动脉瘤 (AAA) 具有显著的破裂风险,需要诊断和预后工具.
- 识别与AAA病原体相关的生物标志物对于临床管理至关重要.
- 阳位子发射断层扫描 (PET) 图像可能提供对AAA活动的见解.
研究的目的:
- 在AAA患者中研究循环生物标志物和[18F]FDG PET/CT阳性之间的关系.
- 评估这些生物标志物和PET发现对AAA增长率的预测价值.
主要方法:
- 164名AAA患者接受了[18F]FDG PET/CT和生物标志物分析.
- 121名患者进行了随访成像,以评估AAA进展,平均时间为32.8个月.
- 分析了与炎症,蛋白质分解活性和矩阵调节相关的生物标志物.
主要成果:
- 在17%的患者中,PET呈阳性,而在PET阳性组中,女性比例更高.
- 在PET阳性患者中观察到炎症性 (CRP,CCL18),蛋白质分解性 (MMP9) 和与矩阵相关的 (OPN,OPG) 生物标志物的水平增加.
- 在AAA快速增长 (≥1厘米/年) 的患者中,CRP,MMP9,OPN和OPG均升高.
结论:
- [18F]基线FDG PET/CT阳性与AAA快速增长没有直接关联.
- 较高的C-反应蛋白 (CRP) 水平与AAA增长率有显著的关联,这表明预后效用.
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