通过Cordyceps sinensis提取物激活NAD驱动的Sirtuin:探索促进皮肤寿命的适应性潜力
Ritamaria Di Lorenzo1, Danila Falanga2, Lucia Ricci1
1Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
International journal of molecular sciences
|April 27, 2024
概括
这项研究表明,Cordyceps sinensis提取物 (CsEx) 可以提高皮肤细胞的能量,增加原蛋白,减少纹. 它强调了CsExEx.
科学领域:
- 综合医学是一个整体的医学.
- 皮肤病学 皮肤病学
- 生物化学 生物化学
背景情况:
- 越来越多的人对抗衰老和长寿的传统中医 (TCM) 感兴趣.
- 需要天然生物活性化合物来解决与年龄相关的皮肤问题.
研究的目的:
- 研究一个标准化的Cordyceps sinensis菌素乙醇提取物 (CsEx) 的适应性和增强皮肤的特性.
- 评估CsEx对细胞能量代谢,氧化应激和原蛋白生产的影响.
- 在临床试验中评估CsEx对皮肤寿命的有效性.
主要方法:
- 在体外测试HaCat和皮肤细胞以测量Sirtuin表达,NAD+合成,ATP生产和活性氧物种 (ROS).
- 使用UHPLC-DAD对cordycepin和adenosine含量进行CsEx标准化.
- 40名受试者进行双盲,安慰剂控制的临床试验,以评估皮肤能量和纹减少.
主要成果:
- 在体外,CsEx显著增加了SirT表达 (SirT1,SirT3,SirT6) 和NAD+合成.
- 在皮肤细胞中增加了68%的ATP生产,并在体内增强了皮肤能量值.
- 在体外减少了30%的ROS,并在体外和体内促进了原蛋白的产生.
- 临床试验显示,减少了28.0%的纹,增加了皮肤能量水平.
结论:
- 科迪塞普斯辛尼西斯 (Cordyceps sinensis) 水乙醇提取物 (CsEx) 在调节皮肤细胞能量代谢方面表现出显著的潜力.
- CsEx具有抗氧化剂和增强原蛋白的特性,有利于皮肤的长寿.
- 这些发现支持CsEx作为一种天然剂,可以对抗皮肤衰老,促进皮肤健康.
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