在双相情感障碍中,系统性炎症的季节性变化较高
Sara Dallaspezia1, Vincenzo Cardaci2, Mario Gennaro Mazza1
1Division of Neuroscience, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.
International journal of molecular sciences
|April 27, 2024
概括
双极性障碍 (BD) 患者在秋季和冬季表现出更高的炎症标志物,这表明季节性免疫系统影响. 这些发现可能会为个性化,免疫调节性抑郁症治疗提供信息.
科学领域:
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
- 时间生物学 时间生物学
背景情况:
- 免疫-炎症机制与双相情感障碍 (BD) 有关.
- 中性粒细胞与淋巴细胞的比率 (NLR) 和全身免疫炎症指数 (SII) 在BD患者中较高.
- 免疫的季节性变化及其对BD的影响还未得到充分研究.
研究的目的:
- 调查双相情感障碍中先天性和适应性免疫标志物的季节性节奏.
- 在BD患者,强迫症患者 (OCD) 和健康对照者 (HC) 中跨季比较NLR和SII水平.
主要方法:
- 824名参与者的回顾性研究:321名BD住院患者,255名OCD住院患者和248名HC.
- 对中性粒细胞与淋巴细胞比率 (NLR) 和全身免疫炎症指数 (SII) 的分析.
- 在不同季节 (秋季,冬季,春季,夏季) 的炎症标志物的比较.
主要成果:
- 与HC和OCD组相比,BD患者在秋季和冬季表现出明显更高的NLR和SII.
- 对于BD患者来说,在春季和夏季没有观察到炎症标志物的显著季节性差异.
- 在BD中,这些季节性免疫模式似乎独立于医院环境和药物治疗.
结论:
- 季节性节律特别影响双相情感障碍中的全身炎症标志物.
- 在抑郁症中,炎症是潜在的治疗点.
- 考虑到季节性变化对于开发针对BD的个性化免疫调节疗法至关重要.
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