在一次性副甲状腺功能障碍症中,TRPC3被降低调节
Emilie Kirstein1, Dirk Schaudien2, Mathias Wagner3
1Institute for Anatomy and Cell Biology, Saarland University, 66421 Homburg, Germany.
International journal of molecular sciences
|April 27, 2024
概括
暂时受体潜在规范 (TRPC) 通道,特别是TRPC3和TRPC6,在人类甲状腺腺体表达. 在一次性甲状腺功能障碍症 (pHPT) 中,TRPC3水平较低,这表明TRPC3在激素调节中的作用.
科学领域:
- 身体生理学 身体生理学
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
背景情况:
- 平衡至关重要,涉及甲状腺.
- 暂时受体潜在正规 (TRPC) 通道,特别是TRPC3和TRPC6在甲状腺功能中的作用在很大程度上是未知的.
- TRPC3与平衡有关,但其甲状腺表达没有特征.
研究的目的:
- 为了研究TRPC3和TRPC6在健康和患病的人类副甲状腺的蛋白质表达.
- 为了确定TRPC3和TRPC6在甲状腺中的细胞局部.
- 探索TRPC3和TRPC6表达在一次性甲状腺功能障碍症 (pHPT) 中的潜在差异.
主要方法:
- 免疫组织化学使用对TRPC3和TRPC6的淘汰验证抗体.
- 从健康个体和pHPT患者手术样本的分析.
- 基于软件的定量分析 (类似H分数).
主要成果:
- TRPC3和TRPC6蛋白质表达在人甲状腺的主要细胞和氧性细胞中.
- 这是对甲状腺组织中TRPC3和TRPC6蛋白表达的首次描述.
- 与健康组织相比,患病 (pHPT) 副甲状腺组织的TRPC3染色分数显著较低.
结论:
- 人类副甲状腺腺体中存在TRPC3和TRPC6蛋白质.
- 在pHPT中,TRPC3的表达被改变,这表明它在对甲状腺激素分泌调节中的作用.
- 需要进一步的研究来证实这些发现,并阐明TRPC3和TRPC6在甲状腺体生理学和病理学的功能意义.
关键词:
这就是CaSR CaSR.TRPC3 TRPC3 是一个非常有价值的东西.TRPC6 TRPC6 是一个人类 人类 人类 人类 人类 人类 人类免疫组织化学 免疫组织化学副甲状腺腺体 副甲状腺体原发性副甲状腺功能障碍症.更多相关视频
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.6K
08:27Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
Published on: January 7, 2019
9.5K
相关概念视频
00:59The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:12GPCR Desensitization
6.0K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.0K
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
00:51Synthesis and Functions of Calcitonin
1.8K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.8K
01:09GPCRs Regulate Adenylyl Cylase Activity
5.5K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.5K