环境暴露于持久有机污染物及其与子宫内膜异位症风险的关联:对表皮-介质细胞过渡过程的影响
Ana Martín-Leyva1, Francisco M Peinado2,3, Olga Ocón-Hernández2,4
1Radiology and Physical Medicine Department, University of Granada, E-18016 Granada, Spain.
International journal of molecular sciences
|April 27, 2024
概括
持续性有机污染物 (POPs) 暴露与子宫内膜异位症风险增加有关,并且可能导致子宫内膜组织的上皮质-介质细胞过渡 (EMT),这表明它在疾病的发展和进展中发挥了作用.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
背景情况:
- 子宫内膜异位症是一种复杂的妇科疾病,具有多因素的病因.
- 持久性有机污染物 (POP) 是具有潜在内分泌干扰性质的环境污染物.
- 表皮-介质细胞转换 (EMT) 是一个细胞过程,与子宫内膜异位症的发病有关.
研究的目的:
- 调查特定的POPs脂肪组织度与子宫内膜异位症风险之间的关联.
- 检查POP暴露与子宫内膜组织中EMT相关基因的表达之间的关系.
主要方法:
- 一项涉及109名妇女的病例控制研究 (34例,75例对照).
- 在手术期间采集脂肪和子宫内膜组织样本.
- 对9种POP的量化和36种EMT相关基因的基因表达概况.
- 包括多变量逻辑回归和斯皮尔曼相关性/曼-惠特尼U测试在内的统计分析.
主要成果:
- 增加子宫内膜异位症的风险与p,p'-DDT,PCB-180和SPCBs有关.
- POP暴露与表皮标记物CLDN7.7的表达下降相关.
- 暴露于POP与中酶体标志物ITGB2和几个EMT促进体 (例如,HMGA1,HOXA10,FOXM1) 的表达增加有关.
结论:
- 脂肪组织中POP度可能与子宫内膜异位症的风险增加有关.
- 通过EMT,POP暴露可能会影响子宫内膜异位症的发展和进展.
- 需要进一步的研究来证实这些发现,并阐明潜在的机制.
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