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微RNA媒介抑制质细胞系衍生的神经营养因子表达是由精神分裂症相关的非编码多态度调节的

Gergely Keszler1, Bálint Vékony2, Zsuzsanna Elek1

  • 1Department of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, 1094 Budapest, Hungary.

International journal of molecular sciences
|April 27, 2024
PubMed
概括

质细胞系衍生的神经营养因子 (GDNF) 基因,rs11111'G'等位基因的特定遗传变异与精神分裂症有关. 这种变异可能会通过微RNA调节减少GDNF表达,影响多巴胺基神经元的存活率.

关键词:
3′-未翻译区域 (3′-UTR)遗传关联分析 遗传关联分析质细胞系衍生的神经营养因子 (GDNF)这是一个小RNARNA.精神分裂症是一种精神分裂症.单个核酸的多态性.

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