牙周炎:神经退行性疾病的一个可信的可修改的风险因素? 一个全面的审查
Adelina S Plachokova1, Jolijn Gjaltema1, Eliza R C Hagens1
1Department of Dentistry, Radboud University Medical Center, 6525 EX Nijmegen, The Netherlands.
International journal of molecular sciences
|April 27, 2024
概括
牙周炎与阿尔茨海默病有关,可能有双向关系. 需要更多的研究来了解牙疾病和神经退行性疾病 (如帕金森病) 之间的联系.
科学领域:
- 口腔健康和神经病学
- 神经炎症研究 神经炎症研究
背景情况:
- 牙周炎是一种慢性炎症性牙疾病,与神经退行性疾病具有共同的风险因素.
- 新出现的证据表明,口腔健康和大脑健康之间存在潜在的联系.
研究的目的:
- 审查有关牙周炎和神经退行性疾病的文献.
- 探索双向关系和病变的产生.
- 为了确定共同的风险因素.
主要方法:
- 系统审查和PubMed,Medline和EMBASE的元分析.
- 包括6篇精选文章和其他相关论文.
- 机械路径和风险因素的分析.
主要成果:
- 在牙周炎和阿尔茨海默病之间发现了显著的关联 (OR 3-5).
- 牙周炎和帕金森病的证据较弱,但与口腔健康不佳的相关性已被注意到.
- 假设幽默,神经和细胞通路涉及牙周病原体,如 * Porphyromonas gingivalis *.
结论:
- 牙周炎症可能导致神经炎症,将牙周炎与神经退行联系起来.
- 常见的风险因素如年龄,遗传和生活方式都会影响这两种情况.
- 牙医和神经病学家之间的跨学科合作对于未来的研究至关重要.
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