与糖尿病病相关的病理生理过程的跨域文本挖掘
Krutika Patidar1, Jennifer H Deng2, Cassie S Mitchell2,3
1Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, NY 14260, USA.
International journal of molecular sciences
|April 27, 2024
概括
人工智能确定了驱动糖尿病病 (DKD) 和质内皮功能障碍的关键信号通路. 这一发现有助于理解DKD.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 糖尿病病 (DKD) 是全球末期病的主要原因.
- 淋巴细胞内皮功能障碍是DKD病变的关键因素.
研究的目的:
- 确定参与DKD中的质内皮功能障碍的信号驱动器和途径.
- 在DKD研究中利用人工智能进行基于文献的发现.
主要方法:
- 使用SemNet 2.0.0进行超过3300万篇PubMed文章的跨域文本挖掘.
- 基因和蛋白质的分析和排名使用正常化的平均HeteSim得分.
- 从高级基因和蛋白质构建一个蛋白质-蛋白质相互作用网络.
主要成果:
- 鉴定了关键的基因和蛋白质交叉DKD,免疫反应和质内皮细胞.
- 将排名最高的概念映射到生物功能中,包括血管生成,炎症和信号通路 (例如NFκB,JAK/STAT,WNT/β-catenin).
- 在DKD相关的失调信号传递中涉及的优先分子和相互作用.
结论:
- 人工智能支持的文献挖掘有效地识别了DKD中的关键信号通路.
- 这些发现为进一步的实验验证和DKD治疗标识提供了基础.
- 了解这些途径对于开发糖尿病病的新疗法至关重要.
关键词:
人工智能的人工智能是人工智能.生物医学文本挖掘 生物医学文本挖掘糖尿病病 糖尿病病疾病相关性疾病相关性功能本体学是一个功能本体学.质内皮细胞是质内皮细胞.免疫反应的免疫反应.机器学习是机器学习.更多相关视频
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