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在COVID-19患者中,通过黑素治疗恢复了Redox恒温变化:一项初步研究

María Elena Soto¹, Israel Pérez-Torres², Linaloe Manzano-Pech²

¹Research Direction, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.

International journal of molecular sciences

|April 27, 2024

概括

黑色素 (MT) 治疗通过增强抗氧化酶活性,恢复了COVID-19患者的氧化还原平衡. 这表明MT可以作为SARS-CoV-2感染的有效辅助疗法.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
医学科学医学科学医学科学

背景情况:

SARS-CoV-2 感染的目标是II型肺细胞,破坏了氧化还原稳定,并增加了活性氧物种 (ROS).
黑素 (MT) 具有抗氧化特性,并保护线粒体功能,使其成为潜在的治疗剂.

研究的目的:

调查黑激素 (MT) 治疗是否可以抵消COVID-19患者血清中观察到的氧化还原稳定性改变.
评估MT对COVID-19患者氧化应激标记物和抗氧化酶活性的影响.

主要方法:

从COVID-19患者的血清样本中分析了氧化应激标志物,包括碳,谷氨 (GSH),总抗氧化能力 (TAC),酸盐和脂质过氧化 (LPO).
在MT治疗前后评估了关键抗氧化酶如谷氨过氧化酶 (GPx),谷氨-S转移酶 (GST),硫素减少酶 (TrxR) 和细胞外超氧化物转移酶 (ecSOD) 的酶活性.
该研究还研究了MT对葡萄糖恒温的作用和华堡效应.

主要成果:

在COVID-19患者中,LPO和碳酸盐显著增加,TAC,酸盐,醇和GSH的含量下降.
MT治疗导致几种抗氧化酶的活性降低,但最终有利于整体抗氧化酶活性,增加TAC并恢复氧化还原平衡.
黑色素调节葡萄糖平衡,作为一种甘油溶解剂,抑制华堡效应.

结论:

黑色素 (MT) 有效地恢复了COVID-19患者的改变的氧化还原平衡.
由于其恢复氧化还原平衡和调节葡萄糖代谢的能力,MT显示出作为SARS-CoV-2感染的辅助疗法的潜力.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.抗氧化酶是一种抗氧化酶.黑激素是什么意思黑激素是什么意思氧化应激是一种氧化应激.氧化还原稳态 (redox homeostasis) 是一种反氧化稳态.

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