探索结肠直肠癌中的关键信号通路和ncRNA
Yun Ju Lee1,2, Woo Ryung Kim1,2, Eun Gyung Park1,2
1Department of Integrated Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
International journal of molecular sciences
|April 27, 2024
概括
结肠直肠癌 (CRC) 涉及关键的信号通路被环境因素破坏. 非编码RNAs (ncRNAs) 调节这些通路,为CRC提供潜在的诊断和治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症诊断和死亡的主要原因.
- 迫切需要有效的诊断和治疗策略,因为随着CRC进展,无病生存率下降.
研究的目的:
- 审查与结直肠癌病原发生有关的关键信号通路.
- 探索非编码RNAs (ncRNAs) 在这些途径中的调节作用.
- 确定CRC的潜在诊断和治疗点.
主要方法:
- 关于CRC中信号通路的文献综述.
- 分析非编码RNAs (ncRNAs) 的作用,包括微RNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs).
- 检查ncRNAs和关键信号通路之间的相互作用:Wnt,PI3K/AKT/mTOR,MAPK,TGF-β和p53.
主要成果:
- 在CRC发育中,五个关键信号通路 (Wnt,PI3K/AKT/mTOR,MAPK,TGF-β,p53) 是至关重要的.
- ncRNAs在这些途径中显著调节基因表达.
- 改变的ncRNA表达模式与CRC进展有关.
结论:
- ncRNAs是CRC中基因表达的关键调节者.
- 失调的ncRNA和信号通路为CRC诊断和治疗提供了有希望的目标.
- 对ncRNA介导路径调节的进一步研究可以促进CRC管理.
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