在雄性大鼠肠道微生物组的型依赖益生菌调节的变化 in vivo 和 in Vitro
Nikolay Kolzhetsov1, Natalia Markelova1, Maria Frolova1
1Laboratory of Functional Genomics of Prokaryotes, Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
International journal of molecular sciences
|April 27, 2024
概括
含有Bifidobacterium longum和Lacticaseibacillus paracasei的益生菌会改变大鼠的肠道微生物组. 便微生物群落可以作为优化居民细菌反应的模型.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 益生菌研究 益生菌研究
背景情况:
- 乳酸细菌长期以来一直被认为具有有益的特性.
- 近几十年来,人们对益生菌的兴趣越来越大,因为肠道微生物群对人类健康的关键作用.
- 益生菌维持肠道微生物群平衡的能力是关键焦点.
研究的目的:
- 为了评估特定益生菌 (Bifidobacterium longum和Lacticaseibacillus paracasei) 对雄性大鼠肠道微生物群的影响.
- 评估这些益生菌菌株在便生物群中的持久性.
- 为了比较肠道微生物群中的益生菌诱导的变化,无论是体外还是体外.
主要方法:
- 对雄性大鼠肠道微生物组合的分析.
- 使用一种含有Bifidobacterium longum和Lacticaseibacillus paracasei的益生菌.
- 在体外和体内对微生物社区反应的比较分析.
主要成果:
- 在老鼠便微生物组中发现了两种不同的肠型.
- 一次的益生菌剂量改变了微生物组成;重复剂量引起了暂时的变化.
- 便微生物组在体外保留了肠型的同一性,在E2生物群中观察到一些体外和体内相似之处.
结论:
- 研究中的益生菌显著影响大鼠肠道微生物组合.
- 便微生物群体在维持肠型认同方面表现出弹性.
- 来自便的微生物群落显示出研究细菌反应的模型系统的潜力.
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