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干扰素-玛分泌在第三阶段乳腺癌患者显著下降

Jung Im Yi¹, Jean Schneider², Seung Taek Lim¹

¹Department of Surgery, The Catholic University of Korea St. Vincent's Hospital, Suwon 16247, Republic of Korea.

International journal of molecular sciences

|April 27, 2024

概括

通过干扰素- (IFN-γ) 分泌量测量的外围自然杀手 (NK) 细胞活性与乳腺癌阶段和体重指数有关. 较低的NK细胞活性可能表明侵袭性乳腺癌患者的风险更高.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物化学生物化学

背景情况:

在诊断时,女性侵袭性乳腺癌患者的外围自然杀手 (NK) 细胞活动的临床相关性研究有限.
以前的研究表明,瘤透NK细胞和分子亚型之间存在潜在的联系.

研究的目的:

研究外围NK细胞活动的临床相关性,特别是干扰素- (IFN-γ) 分泌,在诊断时女性侵袭性乳腺癌患者.
探索NK细胞活动和临床病理参数之间的关系,包括瘤阶段,淋巴结转移和体重指数 (BMI).

主要方法:

对396名接受治疗性手术治疗的女性侵入性乳腺癌患者的回顾性分析.
通过酶相关免疫吸收试验 (ELISA) 测量外围NK细胞活性,以量化IFN-γ分泌.
为了评估与临床病理参数的相关性,进行了统计分析,包括单变量分析,二进制子组分析与不同的IFN-γ分泌截止值 (100pg/mL和250pg/mL),以及ANOVA后期测试 (Bonferroni).

主要成果:

外围NK细胞活性 (IFN-γ分泌) 与瘤分期和体重指数 (BMI) 有显著的相关性.
较低的IFN-γ分泌 (<100 pg/mL) 与晚期III期疾病,状淋巴结阳性,N期增加和更高的BMI有关.
较低水平的IFN-γ分泌与增加的BMI相关,并且在状淋巴结阳性和预后不良的患者中更为明显,例如中性细胞/淋巴细胞 (N/L) 和血小板/淋巴细胞 (P/L) 比率升高的预后因素.

结论:

通过IFN-γ分泌来表明的外围NK细胞活性,在侵袭性乳腺癌患者中具有临床意义.
外围IFN-γ分泌测试可以作为一种方便且有用的工具,用于高风险的侵袭性乳腺癌患者的治疗前风险评估.
这种测试可以帮助识别可能受益于进一步治疗的患者,例如免疫疗法.

关键词:

在 NK 细胞中,NK 细胞是 NK 细胞.乳腺癌乳腺癌乳腺癌干扰素 - 玛干扰素自然杀手细胞是自然杀手细胞.

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