在GSTM1和GSTP1的多态性影响结直肠腺癌的结果
Milica Stojkovic Lalosevic1,2, Vesna Coric2,3, Tatjana Pekmezovic2,4
1Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Medicina (Kaunas, Lithuania)
|April 27, 2024
概括
谷氨转移酶 (GST) 基因变异,特别是GSTM1-null和GSTP1变异基因型,与较差的结直肠癌 (CRC) 存活率有关. 此外,GSTM1-null基因型也表明,在接受FOLFOX6.6治疗的患者中,生存时间更短.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 药物基因组学 药物基因组学
背景情况:
- 结肠直肠癌 (CRC) 往往是在晚期诊断出来的,因此需要有效的治疗方法,比如基于氧沙的化疗.
- 谷氨转移酶 (GSTs) 在CRC的发展和化学疗法药物 (如酸) 的排毒中发挥作用.
研究的目的:
- 研究特定的谷氨转移酶 (GST) 遗传变异对结直肠癌 (CRC) 患者预后的影响.
- 评估这些GST变体对基于氧沙的化疗疗法 (FOLFOX6) 的疗效的影响.
主要方法:
- 对523名CRC患者 (2014-2016) 的前性研究,随访时间中位数为43.47个月.
- 对109名用FOLFOX6.6治疗的晚期CRC患者的分析.
- 卡普兰-梅尔生存分析和Cox对GST基因型和整体生存的比例危险回归.
主要成果:
- GSTM1-null和GSTP1 IleVal+ValVal基因型与CRC患者的总生存时间较短显著相关 (p=0.001).
- 与GSTM1-活性个体相比,接受基于5-甲 (5-FU) 的治疗的GSTM1-零基因型患者的存活时间明显较短 (p=0.05).
结论:
- 在结直肠癌中,GSTM1-null和GSTP1变异基因型是显著的负预后标志物.
- 在接受FOLFOX6化疗的CRC患者中,GSTM1-null基因型可能会预测较差的结果.
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