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相关概念视频

Brain Imaging01:14

Brain Imaging

228
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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精神分裂症中的大脑异常:比较形象学研究

Paula Simina Petric1,2, Petru Ifteni1,2, Ana Aliana Miron1,2

  • 1Facultatea de Medicină, Universitatea Transilvania din Brașov, Bulevardul Eroilor 29, 500036 Brașov, Romania.

Medicina (Kaunas, Lithuania)
|April 27, 2024
PubMed
概括

这项关于精神分裂症大脑变化的研究发现,与第一发病患者和对照患者相比,慢性疾病患者的脑室扩大和前额叶密度发生变化. 这些神经解剖学的差异突显了疾病的进展.

关键词:
大脑CT (计算机断层扫描)大脑密度的大脑密度第一个精神病发作.神经成像是一种神经成像.精神分裂症是一种精神分裂症.

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科学领域:

  • 神经成像和精神病学研究
  • 神经发育障碍 神经发育障碍
  • 精神分裂症研究 精神分裂症研究

背景情况:

  • 精神分裂症越来越被视为神经发育障碍.
  • 神经成像研究将精神疾病与大脑结构功能变化联系起来.
  • 了解精神分裂症的神经解剖学进展至关重要.

研究的目的:

  • 为了比较第一次精神分裂症 (FES) 的结构性大脑变化与慢性精神分裂症 (SCZ) 的结构性大脑变化.
  • 识别与精神分裂症不同阶段相关的不同神经解剖特征.
  • 为了研究不同患者群体内心室大小和额叶密度的差异.

主要方法:

  • 有149名参与者的前性研究:51名FES,49名SCZ (>5年),50名对照.
  • 对所有参与者进行了脑CT检查.
  • 对心室尺寸和额叶密度的比较分析.

主要成果:

  • 观察到额头角和侧腔室的逐渐扩大:SCZ > FES > 控制.
  • 第三心室尺寸在SCZ和FES之间有所不同.
  • 与对照组相比,FES和SCZ组的第四心室测量量更大.
  • 与FES和对照组相比,SCZ的额叶密度更高;FES显示左后皮层密度高于对照组.

结论:

  • 截然不同的心室模式和额叶密度标志着精神分裂症的不同阶段.
  • 与FES患者相比,SCZ患者表现出更大的心室扩张.
  • 神经解剖学的差异凸显了精神分裂症的渐进性质.