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以前患有子宫内膜异位症的患者的乳腺癌显示出低侵略性亚型

Gianluca Vanni¹, Aikaterini Selntigia², Valentina Enrica Marsella¹

¹Breast Unit, Department of Surgical Science, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.

Medicina (Kaunas, Lithuania)

|April 27, 2024

概括

患有子宫内膜异位症的患者患有侵袭性乳腺癌的风险较低,其特点是雌激素受体 (ER) 表达率较高,Ki 67和HER2+水平较低. 子宫内膜异位症的类型或严重程度没有影响乳腺癌的发生.

科学领域:

妇科妇科医生妇科
在瘤学瘤学.
病理学病理学病理学

背景情况:

子宫内膜异位症和乳腺癌之间的联系仍在争论中.
调查与子宫内膜异位症相关的乳腺癌亚型和标志物至关重要.

研究的目的:

为了比较乳腺癌亚型,激素受体和无子宫内膜异位症和 (或) 腺质症患者的增殖指数.
为了确定子宫内膜异位症是否影响乳腺癌的攻击性.

主要方法:

一项病例对照研究比较了三个组:患有子宫内膜异位症的乳腺癌 (BC+EN+),没有子宫内膜异位症的乳腺癌 (BC+EN-),和没有乳腺癌的子宫内膜异位症 (BC-EN+).
乳腺癌亚型,激素受体 (ER) 和Ki 67增殖指数的组织学和免疫组织化学分析.
41个BC+EN+病例与82个BC+EN-和82个BC-EN+患者的匹配.

主要成果:

与没有子宫内膜异位症的患者相比,患有子宫内膜异位症和乳腺癌 (BC+EN+) 的患者表现出更高的雌激素受体 (ER) 表达 (83%对70%).
BC+EN+组显示显著较低的Ki 67增殖指数 (15%对24%) 和HER2+状态 (9.8%对28%).
这些差异在绝经前妇女中更为明显;在绝经后患者中没有发现显著差异. 子宫内膜异位症的特征与乳腺癌的发生没有相关性.

结论:

子宫内膜异位症与不那么激进的乳腺癌亚型有关,这与更高的ER和更低的Ki 67和HER2+有关.
子宫内膜异位症的特定类型或严重程度似乎没有影响乳腺癌的发生.

关键词:

乳腺癌亚型乳腺癌亚型乳腺疾病乳腺疾病乳腺新生瘤的发生.内分泌乳腺疾病内分泌乳腺疾病子宫内膜异位症是什么子宫内膜异位症是什么免疫表因型的确定不孕不育女性女性不孕不育乳腺的恶性瘤.生殖生殖的繁殖.三重阴性乳腺癌是什么

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