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在22q11.2删除综合征中认知功能障碍的神经解剖学相关性

Simon Smerconish¹, James Eric Schmitt¹

¹Departments of Radiology and Psychiatry, Division of Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

|April 27, 2024

概括

22q11.2删除综合征 (22q11.2DS) 由于大脑结构的变化导致认知缺陷. 本综述将神经成像发现与22q11.2DS患者的这些神经认知挑战联系起来.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
发展生物学发展生物学

背景情况:

22q11.2删除综合征 (22q11.2DS) 是最常见的染色体微删除.
它会导致各种各样的解剖学,行为和认知问题.
在22q11.2DS的认知缺陷包括智力能力,执行功能,注意力和社会情感技能.

研究的目的:

在22q11.2DS.中审查和分类有关结构功能关系的现有研究.
探索结构性大脑异常在多大程度上解释了认知缺陷.
为了比较22q11.2DS的发现与类似的人群.

主要方法:

综合结构神经成像和认知评估数据的文献综述.
对特定区域的大脑变化的分析 (体积,厚度,表面积).
检查异常的正面-尾尾梯度的检查.

主要成果:

结构神经成像显示在22q11.2DS.DS中发生了显著的大脑变化.
这些变化显示出特定区域的变化和面角-尾尾梯度.
目前有限的研究将特定的结构变化与认知缺陷联系起来.

结论:

结构性脑部异常是22q11.2DS.的特征.
需要进一步的研究来建立明确的结构功能关系.
了解这些关系可以澄清22q11.2DS.DS的神经认知特征.

关键词:

22q11.2 删除综合征这就是为什么MRI是MRI.认知表型认知表型神经成像是一种神经成像.

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Language and Cognition

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Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.