探索adiponectin在自体主导脏疾病:洞察力和影响
Ersilia Nigro1,2, Marta Mallardo3, Maria Amicone4
1CEINGE-Biotecnologie Avanzate Scarl "Franco Salvatore", Via G. Salvatore 486, 80145 Naples, Italy.
Genes
|April 27, 2024
概括
较低的腺素水平和特定的ADIPOQ基因变异与更糟糕的自身主导性多囊性病 (ADPKD) 结果有关. 这些因素可能有助于了解ADPKD患者的疾病进展和代谢功能障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 是一个遗传学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 自体主导多囊性病 (ADPKD) 是一种常见的遗传性病.
- 在ADPKD中观察到代谢功能障碍,包括胰岛素抵抗和炎症.
- 一个关键的阿迪波金 (adipokine) 之一的阿迪波涅丁 (adiponctin) 在能量,炎症和氧化过程中起作用,但其在ADPKD中的作用尚不清楚.
研究的目的:
- 研究PPARγ,ADIPOQ,ADIPOR1和ADIPOR2和ADPKD中的基因变异之间的关联.
- 分析ADPKD患者的阿迪波内克丁水平和寡合化.
- 探索阿迪波涅克丁,其基因变体和ADPKD严重程度之间的关系.
主要方法:
- 用PCR-Sanger测序分析了92名ADPKD患者的基因变异.
- 使用ELISA和Western Blot测量阿迪波内克丁水平和寡合化.
- 统计分析将阿迪波涅克丁水平和基因型与EGFR,白蛋白和肌素等临床参数相关联.
主要成果:
- 在PPARγ,ADIPOQ,ADIPOR1和ADIPOR2基因中发现了几种单核酸多态 (SNP).
- 与对照组相比,ADPKD患者的阿迪波涅克丁水平显著较低,并且在末期脏疾病 (ESRD) 患者中甚至更低.
- 较低的阿迪波涅丁水平与降低的EGFR相关,并且与ADIPOQ rs1501299 SNP有显著的关联.
结论:
- 亚迪波涅丁水平和ADIPOQ rs1501299基因型与更糟糕的ADPKD表型有显著的关联.
- 这些发现表明,阿迪波涅丁和特定的遗传变异可能成为ADPKD的重要生物标志物.
- 需要进一步的研究来阐明阿迪波内克丁在ADPKD中的病理生理学作用.
关键词:
在ADIPOQQ中,ADIPOQ是最重要的.在 ADPKD1-21-2 中.在PPARγ中,PPARγ是PPARγ国家统一计划 (SNP) 是一个国家统一计划.没有任何的Adiponectin.更多相关视频
08:46Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
9.8K
07:35Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
11.5K
相关概念视频
01:21External Anatomy of the Kidney
1.0K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.0K
01:10Nephrons
2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
01:24Renal Tubule and Collecting Duct
950
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
950
01:25Antihypertensive Drugs: Direct Renin Inhibitors
606
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
606
01:20Renal Corpuscle
2.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.0K
01:12Internal Anatomy of the Kidney
1.6K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.6K