玉米花提取物及其活性成分通过向大麻素受体和调节肠道微生物群来缓解德甲诱导的肌肉损耗
Ngoc Bao Nguyen1,2, Tam Thi Le1, Suk Woo Kang1
1Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea.
Nutrients
|April 27, 2024
概括
玉米花提取物 (CC) 通过促进肌肉生长和减少分解来打击肌肉消耗. 它直接作用于肌肉细胞,间接通过肠道微生物群,为肉类症提供了有前途的治疗方法.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 标志着肌肉质量和力量下降的萨科佩尼亚与衰老和葡萄糖皮质激素使用有关.
- 葡萄糖皮质醇诱导的肌肉缩是一个重大的临床挑战.
- 确定用于肌肉消耗的新型治疗剂至关重要.
研究的目的:
- 评估玉米花 (Centaurea cyanus) 水提取物 (CC) 在预防和治疗肌肉缩方面的疗效.
- 阐明CC对德克萨米他诱导的肌肉衰竭的保护作用的分子机制.
- 探索肠道微生物群在CC治疗作用中的作用.
主要方法:
- 使用C2C12菌管进行体外研究,以评估CC对氧化应激,肌纤维生长和ATP产生的影响.
- 在体内实验中,使用德克萨米他诱导的肌肉衰竭的动物模型进行实验.
- 分子分析包括蛋白质降解/合成标记物,线粒体含量和信号通路.
- 对接分析以确定CC化合物的潜在分子标.
- 肠道微生物组分析和与肌肉质量的相关性.
主要成果:
- CC及其化合物减轻了氧化应激,增强了肌纤维生长,并在体外增加了ATP的产生.
- 在体内,CC治疗减轻了德甲诱导的肌肉衰竭,改善了握力和运动表现.
- CC调节的肌肉基因表达与差异化,蛋白质循环和运动有关.
- CC丰富了肠道微生物的多样性,Clostridium sensu stricto 1的丰度和肌肉质量之间存在正相关性.
- 来自CC的Graveobioside A被确定为大麻素受体 (CB1/CB2) 的潜在调节器,影响蛋白质合成和降解.
结论:
- 玉米花提取物 (CC) 在预防和治疗肌肉缩方面表现出显著的潜力.
- CC具有多方面的作用,包括肌肉大麻素受体的直接调节和通过肠道微生物群的间接影响.
- CC代表了对缩症和药物诱导的肌肉衰竭的有前途的治疗策略.
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