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塔拉克萨西草 () 对大鼠 propionate 诱导的良性前列腺增生的影响
Seong Min Lee1, Sang Mok Lee1, Jungbin Song1
1Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Nutrients
|April 27, 2024
概括
塔拉克萨西草本 (丹) 提取物有效地抑制了大鼠良性前列腺激增症 (BPH) 的进展. 这种天然疗法减少了前列腺大小,并调节了参与BPH发展的关键分子通路.
科学领域:
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 草药是一种草药.
背景情况:
- 良性前列腺增生 (BPH) 是一种常见的疾病,导致下泌尿道症状 (LUTS).
- 塔拉克萨西草 (TH) 或 dandelion,在东亚有着传统的使用历史,用于管理LUTSs.
- 对于BPH的TH的治疗潜力在科学研究中仍未得到充分探索.
研究的目的:
- 研究Taraxaci Herba (TH) 提取物对良性前列腺增生 (BPH) 进展的抑制作用.
- 为了评估TH的疗效,使用酸诱导的BPH大鼠模型来评估TH的疗效.
主要方法:
- 良性前列腺增生 (BPH) 在雄性Sprague Dawley大鼠中通过皮下 propionate注射 (3 mg/kg/天) 在割后28天诱导.
- 在整个研究期间,老鼠同时服用TH提取物口服剂量 (100和300毫克/公斤/天).
- 评估了前列腺体重,组织病理变化,血清激素水平 (,二),雄激素受体表达和与亡相关的蛋白质 (Bax,Bcl-2).
主要成果:
- TH提取物显著降低了前列腺的体重 (绝对和相对),并改善了与BPH相关的组织病理变化.
- 服用TH提取物导致丸激素和二丸激素的血清水平降低.
- TH提取物调节了雄激素受体表达,并改变了Bax和Bcl-2的蛋白质水平,它们是细胞亡的关键调节者.
结论:
- 塔拉克萨西草本 (TH) 提取物对良性前列腺增生 (BPH) 的发展表现出显著的抑制作用.
- TH的作用机制涉及对雄激素信号通路的调节和前列腺细胞中亡的诱导.
- 这些发现支持公英的传统用途,用于管理与BPH相关的下尿路症状.
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