人类牛奶寡糖,生长和身体组成在非常早产的婴儿
Margaret L Ong1, Sara Cherkerzian1, Katherine A Bell1
1Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nutrients
|April 27, 2024
概括
人母乳寡糖化物 (HMO) 没有显著影响非常早产婴儿的生长. 较高的HMO摄入量与年龄相应年龄的体型或身体组成的改善无关,除了3FL和头周长的一个例外.
科学领域:
- 新生儿营养新生儿营养
- 儿科生长研究的研究.
- 人类牛奶寡糖的研究研究
背景情况:
- 人类母乳寡糖化物 (HMO) 是母乳中重要的生物活性成分,以其对婴儿健康的益处而闻名.
- 对于非常早产婴儿 (<32周妊娠期) 的生长和发育,HMO对HMO的影响仍然基本上未被描述.
- 了解HMO的作用对于优化脆弱新生儿群体的营养策略至关重要.
研究的目的:
- 在住院期间,为非常早产婴儿提供的母乳中量化HMO度.
- 调查HMO暴露与婴儿大小和身体组成在相当年龄之间的关联.
- 为了确定更高的HMO摄入量是否会影响非常早产婴儿的生长结果.
主要方法:
- 在两个时间点测量82名非常早产婴儿母乳中的HMO度.
- 评估婴儿的人类测量和身体构成使用空气位移囊学术在相当年龄.
- 使用线性混合效应模型进行统计分析,以比较HMO度三位数的增长结果,并对混因素进行调整.
主要成果:
- 在更高的HMO度和人体结构或人体成分z-score在经期校正的年龄之间没有发现显著的关联.
- 观察到中期3 - 富可酸乳糖 (3FL) 三度暴露和更大的头周长z-score (0.61,95% CI 0.15,1.07) 之间的关联.
- 总的来说,这项研究不支持这样的假设,即更高的HMO摄入量促进了这一群非常早产婴儿的成长.
结论:
- 在非常早产婴儿的饮食中,母乳寡糖度较高与人体测量或身体组成结果的改善无关.
- 虽然特定的HMO (3FL) 显示出与头周长的潜在关联,但整体HMO摄入量并没有显著影响生长参数.
- 可能需要进一步的研究来探索个体HMO的特定作用及其与早产人口中婴儿生长的复杂相互作用.
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