基于Pullulan的喷雾干燥的粘膜粘合微粒用于持续的口腔粘膜药物输送
Ting Liu1, Xiang Gong2, Yang Cai1
1College of Stomatology, Guizhou Medical University, Guiyang 550004, China.
Pharmaceutics
|April 27, 2024
概括
新的Pullulan微粒提供了增强的口服药物输送. 这些粘粘性颗粒提供持续释放和长时间的停留时间,用于治疗局部口腔疾病.
科学领域:
- 制药技术 制药技术 制药技术
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 粘膜粘合微粒通过增加粘膜接触和停留时间来增强口粘膜药物递送.
- 胺化 (BZH) 是一种用于局部口腔疾病的药物.
研究的目的:
- 开发和描述粘膜粘合剂喷雾干燥的pullulan微粒,用于口腔粘膜输送胺化物 (BZH).
- 为了评估药物释放特征,粘膜粘附和口腔粘膜上BZH载荷的Pullulan微粒的保留.
主要方法:
- 使用普鲁兰和胺化 (BZH) 通过喷雾干燥来制备粘粘性微粒.
- 分析了粒子大小,静止角度,药物释放动力学和粘膜粘合.
- 量化了微封装黄金纳米粒子探针在粘膜上的保留.
主要成果:
- BZH-pullulan微粒的平均大小小小于25微米,流量性能良好 (静止角为25.8-36.6°).
- 普鲁兰显著延长了BZH释放 (>180分钟),大约是奇托桑报告的9倍.
- 粘膜粘合性研究显示,微封装探针在粘膜上保留了高达78.8%的重量.
结论:
- BZH-pullulan微粒显示出在口腔粘膜中药物输送的显著潜力.
- 该配方提供持续的药物释放和延长的in situ停留时间,适用于治疗局部口腔疾病.
- 普鲁兰的粘粘性质有助于提高药物输送效率.
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