喷雾干燥的微封装Bauhinia ungulataL. var.的喷雾干燥的微封装. 含有化合物的水性提取物:使用不同墙壁材料进行比较研究
Myrth Soares do Nascimento Remígio1,2, Teresa Greco2, José Otávio Carréra Silva Júnior3
1Laboratory of Chromatography and Mass Spectrometry, Graduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Pharmaceutics
|April 27, 2024
概括
使用点或碳氧甲基纤维素微封装Bauhinia ungulata叶片提取物增强了其化合物,抗氧化活性和热稳定性,支持其传统的抗糖尿病用途.
科学领域:
- 药物鉴定和植物化学学
- 材料科学与工程 材料科学与工程
- 食品科学与技术 食品科学与技术
背景情况:
- 传统上,被称为"pata-de-vaca"的bauhinia物种用于糖尿病管理.
- 波希尼亚古拉塔的种类. 在亚马逊地区, obtusifolia 叶被用作药用茶.
- 叶子含有有价值的化合物,具有潜在的治疗特性.
研究的目的:
- 用于微封装 Bauhinia ungulata 叶子的冷解水性提取物.
- 评估不同墙壁材料对微粒子特性和生物活性的影响.
- 评估微封装提取物在抗糖尿病应用中的潜力.
主要方法:
- 使用五种墙壁材料进行Bauhinia ungulata叶片提取物的微封装:马尔托德克斯 (DE 4-7,DE 11-14),β-环氧德克斯,点和碳素甲基纤维素.
- 微粒的特征:微观结构,粒子大小分布,热行为,产量和封装效率.
- 使用高性能液态染色学 (HPLC) 量化化合物 (酸,p-酸,鲁丁,异) 和抗氧化活性 (DPPH,ABTS测定).
主要成果:
- 微粒体呈现球形形态,表面纹,颗粒大小在1.155.54微米之间.
- 产量和醇封装效率分别在6083%和3557%之间.
- 用碳甲基纤维素或点制备的微粒显示出优越的热稳定性,更高的黄酸盐含量和增强的抗氧化活性.
结论:
- 微封装有效地保存了来自Bauhinia ungulata叶的化合物,包括酸,p-coumaric酸, rutin 和 isoquercitrin.
- 丁和甲纤维素是微封装Bauhinia ungulata提取物的最佳壁材料,增强其稳定性和生物活性.
- 这些微粒的增强抗糖尿病性质验证了传统的Bauhinia ungulata的使用.
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